An AFP picture taker said the blasts harmed the exterior of a close-by building, burning the greater part of its six stories.
Sayyida Zeinab, south of Damascus, contains the grave of a granddaughter of the Prophet Mohammed and is especially adored as a journey site by Shiite Muslims.
It has kept on pulling in pioneers from Syria and past, especially Shiites from Iran, Lebanon, and Iraq, all through Syria's almost five-year merciless clash.
Sunni Muslim radical gatherings, for example, ISIS consider Shiites to be apostates and have every now and again focused on them in assaults.
In the consequence of Sunday morning's assault, smoke ascended from the curved remains of more than twelve autos and a transport, as ambulances carried away the injured and firefighters attempted to put out blasts.
In an announcement coursed on online networking, ISIS guaranteed obligation regarding the assaults, saying two of its individuals had exploded suicide bombs.
"Two warriors of the caliphate completed affliction operations in a lair of the unbelievers in the Sayyida Zeinab range, executing almost 50 and harming around 120," it said.
The zone around the place of worship has been focused in past bomb assaults, incorporating into February 2015 when two suicide assaults murdered four individuals and injured 13 at a checkpoint.
Likewise that month, an impact tore through a transport conveying Lebanese Shiite travelers made a beeline for Sayyida Zeinab, killing no less than nine individuals, in an assault guaranteed by Al-Qaeda associate Al-Nusra Front.
The range around the holy place is intensely secured with administration checkpoints set up many meters (yards) away to keep vehicles from drawing nearer.
By Observatory, individuals from Lebanon's effective Shiite bunch Hezbollah are among those conveyed at the checkpoints.
Hezbollah is a staunch partner of Syria's President Bashar al-Assad and has dispatched warriors to support his troops against the uprising that started in March 2011 with hostile to government dissents.
At an opportune time, the gathering refered to the risk to Sayyida Zeinab as the inspiration for its mediation in Syria's contention.
More than 260,000 individuals have been slaughtered in Syria's contention, which has likewise uprooted upwards of a large portion of the nation's populace inside and abroad.
It has advanced into a complex, multi-front war including rebels, jihadists, administration and partnered powers, Kurds and air strikes by both government associate Russia and a US-drove coalition fighting against ISIS.
In another push to locate a political answer for the contention, UN Syria emissary Staffan de Mistura has welcomed administration and resistance assignments to Geneva for new talks.
In any case, while the resistance consented to go to Geneva following quite a while of postponements, it has so far declined to take part in circuitous chats with the legislature.
It is requesting that UN Security Council resolutions on closure attacks and ensuring regular citizens be actualized first.
On Sunday, the UN emissary held casual converses with the fundamental resistance appointment, saying a short time later that he stayed "idealistic and decided".
The Damascus assignment's boss arbitrator, Syria's UN agent Bashar al-Jaafari, blamed the resistance for being "not genuine" about the discussions.
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